Lopoten 25 mg (Tablet)
Unit Price: ৳ 4.50 (3 x 10: ৳ 135.00)
Strip Price: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Euro pharma ltd |
| Also available as |
Indications
- Treatment of Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- May be used alone or in combination with other antihypertensive agents
- 25 mg twice daily may be recommended if 50 mg once daily is inadequate
- Total daily dose ranges from 25 mg to 100 mg
Interactions
- Reduced levels of active metabolite with rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increases in serum potassium with potassium-sparing diuretics or supplements
Contraindications
- Contraindicated in pregnant women
- Hypersensitivity to any component of the product
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, and nasal congestion
Pregnancy & Lactation
- Pregnancy Category D
- Higher risk to fetus if administered during second or third trimesters
Precautions & Warnings
- Reduces fetal renal function and increases morbidity and death in second and third trimesters
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children