Losanil 50 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Medicon pharmaceuticals ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor in various tissues
Dosage & Administration
- Usual starting dose of 50 mg once daily
- Total daily dose ranges from 25 mg to 100 mg
- Different dosage for patients upto 75 years and over 75 years
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Effect on serum potassium levels with potassium-sparing diuretics and supplements
- Attenuation of antihypertensive effect by indomethacin
Contraindications
- Contraindicated in pregnant women
- Hypersensitivity to any component of the product
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
Pregnancy & Lactation
- Pregnancy Category D
- Risk to the fetus increases if administered during second or third trimesters
- Unknown excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death during second and third trimesters
- Potential for symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patient
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
- Consideration of lower dose for patients with history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children