Coxitor 120 mg (Tablet)

Unit Price: ৳ 14.00 (2 x 10: ৳ 280.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Etoricoxib
Company Beacon pharmaceuticals plc
Also available as
Coxitor 60 mg tablet Coxitor 90 mg tablet

Title

  • Coxitor 120 mg Tablet

Categories

  • Pharmaceuticals
  • Medicine
  • Pain Relief
  • Anti-inflammatory

Description

  • Selective COX-2 Inhibitor
  • Symptomatic relief for Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, and acute gouty arthritis
  • Short-term treatment for moderate pain associated with dental surgery
  • Orally active cyclooxygenase-2 (COX-2) specific inhibitor
  • Potent and orally active
  • Decreases clinical signs and symptoms with decreased potential for GI toxicity and effects on platelet aggregation
  • Dosage forms: 30 mg, 60 mg, 90 mg, 120 mg
  • Oral administration
  • Therapeutic class: Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indications

  • Relief of pain and signs of inflammation associated with various conditions like OA, RA, ankylosing spondylitis, and acute gouty arthritis
  • Short-term treatment of moderate pain associated with dental surgery

Pharmacology

  • Inhibition of COX-2 without inhibition of COX-1
  • Decreased potential for GI toxicity and effects on platelet aggregation

Dosage and administration

  • Recommended doses for different conditions: 30 mg once daily, 60 mg once daily, 90 mg once daily, 120 mg once daily
  • Duration of treatment for acute gouty arthritis: 8 days
  • Limited to a maximum of 3 days for postoperative dental surgery pain

Interaction

  • Potential interactions with oral anticoagulants, diuretics, ACE inhibitors, Angiotensin II Antagonists, Acetylsalicylic Acid, Ciclosporin, Tacrolimus, and Lithium

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Active peptic ulceration or active GI bleeding
  • Patients with specific allergic-type reactions after taking acetylsalicylic acid or NSAIDs
  • Pregnancy, lactation
  • Severe hepatic dysfunction, estimated renal creatinine clearance <30 ml/min
  • Children and adolescents under 16 years of age
  • Inflammatory bowel disease
  • Congestive heart failure, hypertension, established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease

Side effects

  • Palpitation
  • Fatigue
  • Influenza-like symptoms
  • Ecchymosis
  • Dry mouth
  • Taste disturbance
  • Mouth ulcer
  • Appetite and weight change
  • Atrial fibrillation
  • Transient ischaemic attack
  • Chest pain
  • Flushing
  • Cough
  • Dyspnoea
  • Epistaxis
  • Anxiety
  • Impaired mental acuity
  • Paraesthesia
  • Electrolyte disturbance
  • Myalgia
  • Arthralgia
  • Confusion
  • Hallucinations

Pregnancy and lactation

  • Not recommended for women attempting to conceive
  • Not recommended for breastfeeding women as it is excreted in the milk of lactating rats

Precautions and warnings

  • Caution advised for patients at risk of developing GI complications with NSAIDs
  • Special consideration for patients with significant risk factors for cardiovascular events
  • Caution for patients with renal impairment, hepatic dysfunction, cardiac failure, left ventricular dysfunction, or hypertension
  • Regular monitoring of renal and liver function
  • Discontinue at the first appearance of skin rash, mucosal lesions, or hypersensitivity
  • May mask fever and other signs of inflammation
  • Caution when co-administering with warfarin or oral anticoagulants

Overdose effects

  • Single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity
  • Usual supportive measures recommended in the event of overdose

Storage conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical structure

  • Molecular Formula: C18H15ClN2O2S
  • Chemical Structure: (image URL)

Duration of effect

20-24 hours

Onset of action

1-2 hours, faster on an empty stomach

Habit forming

No

Safe with alcohol

No

Affect on driving

May cause drowsiness, avoid driving

Affect on kidney function

Caution in patients with kidney disease, adjustment of dose might be needed, not recommended in severe kidney disease

Affect on liver function

Caution in patients with liver disease, adjustment of dose might be needed, not recommended in severe liver disease

Quick tips

  • Helps relieve pain and inflammation
  • May cause fewer stomach problems compared to other NSAIDs
  • May cause dizziness and fatigue, avoid activities requiring concentration
  • Avoid alcohol consumption
  • Regular blood pressure monitoring
  • Inform doctor of history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease
  • Regular liver function tests during long-term treatment
  • Not recommended during pregnancy, planning to conceive, or breastfeeding

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