Esoprex MUPS 20 mg (MUPS Tablet)

Unit Price: ৳ 11.00 (5 x 10: ৳ 550.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Beacon pharmaceuticals plc
Also available as
Esoprex mups 40 mg tablet

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • Esomeprazole MUPS 20 Tablet
  • Esomeprazole MUPS 40 Tablet
  • 133.333 mg of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole
  • 266.67 mg of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole

Description

  • MUPS is abbreviation for Multiple-Unit Pellet System
  • Ensures greater bioavailability
  • Uniform emptying of micro pellets from stomach into small intestine
  • Combination of fast acting and sustained action
  • Once daily dosing

Pharmacology

  • Proton pump inhibitor Esomeprazole inhibits gastric acid
  • Effective for short-term treatment of gastric and duodenal ulcers
  • Used in the prevention and treatment of NSAID associated gastric ulcers

Dosage

  • Erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Administration

  • Tablets should be swallowed whole with liquid
  • Should not be chewed or crushed
  • Can be dispersed in half a glass of non-carbonated water
  • Stir until the tablets disintegrate and drink the liquid with the pellets immediately or within 30 minutes

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • Does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
  • May interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

  • Contraindicated in patient with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • Manufacturer advises caution
  • Not known if Esomeprazole or its metabolites appear in human breast milk

Precautions & Warnings

  • Use carefully if the patient has severe liver dysfunction and severe renal impairment
  • Slightly increases the risk of hip, wrist and spine fracture

Storage Conditions

  • Store in a cool & dry place below 25°C
  • Protect from light
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula : C17H19N3O3S

Common Questions

  • PPIs work by reducing the amount of acid produced in the stomach
  • Used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions
  • Relieves heartburn and GERD symptoms
  • Aids in healing erosive esophagitis
  • Effectively prevents erosive esophagitis recurrence
  • Common side effects like headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth
  • No side-effects reported if pregnant or breastfeeding

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