Certus 250 mg (Tablet)

Unit Price: ৳ 350.00 (1 x 35: ৳ 12,250.00)
Strip Price: ৳ 12,250.00

Medicine Details

Category Details
Generic Lapatinib
Company Beacon pharmaceuticals plc

Indications

  • Treatment of advanced or metastatic breast cancer with HER2 overexpression
  • Combination therapy with capecitabine and letrozole

Pharmacology

  • Kinase inhibitor targeting EGFR and HER2 receptors
  • Inhibits ErbB-driven tumor cell growth
  • Absorption after oral administration
  • Highly bound to albumin and alpha-1 acid glycoprotein
  • Extensively metabolized by CYP3A4 and CYP3A5
  • Predominantly metabolized by CYP3A4/5
  • Mainly hepatic elimination

Dosage & Administration

  • Oral dose of 1,250 mg daily
  • Combination with capecitabine and letrozole
  • Dosing instructions for different breast cancer types
  • Administration with or without food

Interaction

  • Inhibition of drug-metabolizing enzymes and transport systems
  • Effects on CYP3A4, CYP2C8, and P-glycoprotein
  • Specific interactions with Midazolam, Paclitaxel, and Digoxin
  • Impact of acid-reducing agents on solubility

Contraindications

  • Severe hypersensitivity reactions

Side Effects

  • Common adverse reactions during treatment
  • Specific adverse reactions with capecitabine and letrozole combination therapy

Pregnancy & Lactation

  • Potential fetal harm
  • Advice for pregnant and lactating women

Precautions & Warnings

  • Decreased left ventricular ejection fraction
  • Hepatotoxicity monitoring and management
  • Management of diarrhea
  • Risk of interstitial lung disease and pneumonitis
  • Potential for QT prolongation
  • Severe cutaneous reactions and associated precautions

Use in Special Populations

  • Dose modification guidelines for cardiac events, hepatic impairment, and diarrhea
  • Interactions with CYP3A4 inhibitors and inducers
  • Management of other toxicities

Overdose Effects

  • No known antidote for overdoses
  • Observations from reported cases of overdose

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store below 30°C in a dry place
  • Keep out of the reach of children

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