Xitabin 150 mg (Tablet)
Unit Price: ৳ 60.00 (5 x 6: ৳ 1,800.00)
Strip Price: ৳ 360.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Capecitabine |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Adjuvant Colon Cancer
- Metastatic Colorectal Cancer
- Metastatic Breast Cancer
- Resistance to paclitaxel and anthracycline-containing regimen
Pharmacology
- Nucleoside metabolic inhibitor
- Orally-administered
- Prodrug
- Enzymatic conversion to fluorouracil
- Inhibition of DNA synthesis
- Selective tumor activation
- Inhibition of thymidylate synthase
- Interference with RNA processing
Dosage & Administration
- Monotherapy dosage: 1250 mg/m2 twice daily orally
- Adjuvant treatment duration: 6 months (8 cycles)
- Combination with docetaxel dosage: 1250 mg/m2 twice daily for 2 weeks
- Individualized dosage based on patient management
- Administration with meals
- Prescribed by experienced oncologist
Interaction
- Monitoring of anticoagulant response
- Phenytoin level monitoring
- Enhanced 5-fluorouracil concentration by leucovorin
- CYP2C9 substrates caution
- Reduced absorption with food
Contraindications
- Severe Renal Impairment
- Hypersensitivity
- Leucopenia, neutropenia or thrombocytopenia
- Severe reactions to fluoropyrimidine therapy
- Complete DPD deficiency
- Pregnancy or breastfeeding
Side Effects
- Abdominal pain
- Rash
- Dry or itchy skin
- Tiredness
- Loss of appetite
- Diarrhea
- Vomiting
- Nausea
- Stomatitis
- Hand-and-foot skin-reaction
- Fever
- Infection
- Chest pain
- Steven-Johnson syndrome
Pregnancy & Lactation
- Pregnancy category D
- Potential fetal harm
- Discontinuation of breastfeeding during treatment
Precautions & Warnings
- Coagulopathy monitoring
- Diarrhea management
- Cardiotoxicity in coronary artery disease patients
- Risk in patients with low or absent DPD activity
- Dehydration and renal failure risk
- Mucocutaneous and dermatologic toxicity
- Hyperbilirubinemia monitoring
- Hematologic parameter restrictions
Overdose Effects
- Nausea
- Vomiting
- Diarrhea
- Mucositis
- Gastrointestinal irritation
- Bone marrow depression
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Dry place
- Temperature below 30°C
- Protection from light
- Keep out of reach of children