Losa 50 mg (Tablet)
Unit Price: ৳ 6.02 (3 x 10: ৳ 180.60)
Strip Price: ৳ 60.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Alco pharma ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- Possible starting dose of 25 mg once daily for intravascular volume-depleted patients
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily for patients over 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use of Losa and hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes may increase serum potassium
- Attenuation of antihypertensive effect with indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Pregnancy
- Hypersensitivity to any component
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects such as fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Higher risk to fetus in second or third trimester
- Potential excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
- Dosage adjustment for renal impairment and hepatic impairment
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children