Losacard 50 mg (Tablet)
Unit Price: ৳ 8.03 (30's pack: ৳ 240.92)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Novo healthcare and pharma ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily recommended if 50 mg is inadequate
- Total daily dose ranges from 25 mg to 100 mg
- Different starting doses for patients under and over 75 years
Interactions
- Reduced levels with rifampicin and fluconazole
- Potentiation with hydrochlorothiazide
- Increased serum potassium with potassium-sparing diuretics or supplements
- Attenuated effect with indomethacin
- Increased risk of renal impairment with certain combinations of drugs
Contraindications
- Pregnancy
- Hypersensitivity to any component of the product
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other less common side effects
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus increases in second or third trimesters
- Unknown excretion in human milk
- Consideration for discontinuing nursing or drug based on importance to mother
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death in second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Renal function changes and renal failure reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment for mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose consideration for patients with hepatic impairment
- Use with caution in patients with intravascular volume depletion
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children