Fixvel 400 mg+100 mg (Tablet)

Indications

• HCV genotype 1-6 infection treatment
• With or without cirrhosis
• In pediatric patients 3 years and older

Pharmacology

• Sofosbuvir NS5B polymerase inhibitor
• Velpatasvir NS5A inhibitor
• Mechanism of action
• Pharmacodynamics
• Cardiac electrophysiology

Dosage & Administration

• Testing prior to therapy
• Recommended treatment regimen and duration
• Dosage in adults and pediatric patients
• Pediatric use
• Dosing for pediatric patients
• Ribavirin dosage recommendations

Interaction

• Potential for other drugs to affect
• Potential for product to affect other drugs
• Established and potentially significant drug interactions

Contraindications

• Contraindicated in patients for whom ribavirin is contraindicated

Side Effects

• Common side effects
• Rare adverse events
• Serious symptomatic bradycardia risk

Pregnancy & Lactation

• Contraindicated in pregnant women and men with pregnant partners if administered with ribavirin
• Unknown effects in breast milk

Precautions & Warnings

• Risk of hepatitis B virus reactivation
• Serious symptomatic bradycardia risk when coadministered with amiodarone
• Risks associated with ribavirin and combination treatment

Use in Special Populations

• Geriatric patients
• Patients with renal impairment
• Patients with hepatic impairment

Overdose Effects

• No specific antidote available
• General supportive measures
• Hemodialysis efficiency

Therapeutic Class

• Hepatic viral infections (Hepatitis C)

Storage Conditions

• Store in cool and dry place
• Keep out of reach of children

Related Brands

• Panovir 400 mg+100 mg (Tablet) - incepta-pharmaceuticals-ltd