Losacor 50 mg (Tablet)
Unit Price: ৳ 9.00 (5 x 6: ৳ 270.00)
Strip Price: ৳ 54.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptors in various tissues
- Reduces vasoconstriction
- Reduces aldosterone release responsible for hypertension
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- Can be used alone or in combination with other antihypertensive agents
- Dose ranges from 25 mg to 100 mg daily
- Different dosage recommendations for patients of different ages
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Possible increases in serum potassium with potassium-sparing diuretics or supplements
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment when combined with certain drugs
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other potential side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased fetal risk if administered during second or third trimesters
- Uncertain excretion in human milk, potential for adverse effects on nursing infant
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death in second and third trimesters of pregnancy
- Potential for symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Reported changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- Different dosage adjustments for renal impairment and intravascular volume depletion
- Consideration of lower dose for patients with hepatic impairment
- Potential interactions with other antihypertensive agents
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children