Losan 25 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Orion pharma ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- 25 mg once daily for patients with intravascular volume depletion
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily for patients over 75 years
Interactions
- Reduced levels with rifampicin and fluconazole
- Potentiation with hydrochlorothiazide
- Increased serum potassium with potassium-sparing diuretics or supplements
- Attenuation by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Pregnancy
- Hypersensitivity to any component
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus increases in second or third trimester
- Decision regarding nursing or drug discontinuation should consider potential adverse effects on the nursing infant
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment for mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children