Doxobron 200 mg (Tablet)

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Doxophylline
Company Team pharmaceuticals ltd
Also available as
Doxobron 400 mg tablet Doxobron 100 mg syrup

Title

  • Doxobron

Categories

  • Medicine
  • Bronchodilator
  • Methyl xanthine derivatives

Description

  • Novel bronchodilator for treating bronchial asthma, bronchospasm, COPD, and pulmonary disease with spastic bronchial component
  • Contains Doxophylline with a dioxolane group in position 7
  • Selective inhibitor of phosphodiesterase 4
  • Reported to inhibit platelet activating factor (PAF) and generation of leukotriene production
  • Dosage: 200-400 mg tablet for elderly, 400 mg tablet for adults, syrup or tablet for children based on age and body weight
  • Interactions with xanthine preparations, caffeine, ephedrine, sympathomimetic drugs, and various medications
  • Contraindicated in individuals with hypersensitivity to xanthine derivatives, acute myocardial infarction, hypotension, and lactating mothers
  • Potential side effects include nausea, vomiting, headache, tachycardia, hyperglycemia, and more
  • Pregnancy and lactation precautions with limited clinical evidence
  • Precautions for patients with cardiac disease, hypertension, hypoxemia, liver disease, renal impairment, and other conditions
  • Potential overdose effects include severe cardiac arrhythmias and tonic-clonic seizure

Indications

  • Bronchial asthma
  • Bronchospasm
  • Chronic obstructive pulmonary disease (COPD)
  • Pulmonary disease with spastic bronchial component

Pharmacology

  • Structurally differs from Theophylline due to the presence of a dioxolane group in position 7
  • Selective inhibitor of phosphodiesterase 4
  • Decreased affinities toward adenosine A1 and A2 receptors
  • Reported inhibition of platelet activating factor (PAF) and leukotriene production

Dosage & Administration

  • 200 mg tablet for elderly, two or three times daily
  • 400 mg tablet for adults, two or three times daily
  • Syrup or tablet for children based on age and body weight
  • Special release (SR) tablet for specific dosage requirements

Interaction

  • Incompatibility with xanthine preparations
  • Cautions for consumption of caffeine and certain medications
  • Possible consequences of concurrent administration with various drugs

Contraindications

  • Hypersensitivity to the drug or other xanthine derivatives
  • Acute myocardial infarction
  • Hypotension
  • Lactation

Side Effects

  • Nausea
  • Vomiting
  • Headache
  • Tachycardia
  • Hyperglycemia
  • Tonic-clonic seizure

Pregnancy & Lactation

  • Limited clinical evidence for use during pregnancy
  • Contraindicated during lactation
  • No effects on ability to drive and use machines

Precautions & Warnings

  • Hepatic clearance reduction factors
  • Special precautions for certain patient groups
  • Recommendation for monitoring blood levels in specific cases

Overdose Effects

  • Severe cardiac arrhythmias
  • Tonic-clonic seizure
  • Absence of specific antidote

Therapeutic Class

  • Bronchodilator
  • Methyl xanthine derivatives

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children
  • Prescription required

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