Esotem 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole |
| Company | Team pharmaceuticals ltd |
| Also available as |
Title and Category
- Esotem 40 mg Capsule
- Proton Pump Inhibitor (PPI)
Color Options
- Clear
Function
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Symptomatic relief of Zollinger-Ellison Syndrome
- Treatment of acid-related Dyspepsia
- Healing of Duodenal & Gastric ulcer
Dosage Form
- Tablet
- Capsule
- Oral Suspension
- IV Injection
Dosage Instructions
- 20 mg or 40 mg Once Daily for 4-8 Weeks for Healing of Erosive Esophagitis
- 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
- 20 mg Once Daily for Symptomatic GERD for 4 Weeks
- 40 mg Once Daily for Helicobacter Pylori eradication
- 20-80 mg Once Daily for Zollinger-Ellison Syndrome
- 20-40 mg Once Daily for Acid-related Dyspepsia
- 20 mg Once Daily for 2-4 weeks for Duodenal ulcer
- 20-40 mg Once Daily for 4-8 weeks for Gastric ulcer
- IV Injection for adults (≥18 years) - 20 mg or 40 mg Once Daily
- IV Injection for Pediatric Patients (1 year to 17 years) - 10 mg Once daily (<55 kg), 20 mg once daily (≥55 kg), 0.5 mg/kg once daily (1 month to <1 year)
- 80 mg IV Infusion for Risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy in adults
Administration Instructions
- Swallow whole and taken one hour before a meal for Tablet or Capsule
- Dilution with water and immediate consumption for Oral Suspension
- IV Injection over a period of at least 3 minutes
Pharmacology
- Proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase
- Absorption in 1.5 hours, increased peak plasma levels with increased dose
- Extensive metabolism in the liver by the cytochrome P450 (CYP) enzyme system
- Limited excretion in the urine
- Combination Therapy with Antimicrobials: Increased AUC and Cmax during triple combination therapy
Interaction
- Metabolized in the liver by CYP2C19 and CYP3A4
- Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
- Potentially interferes with CYP2C19, the major Esotem metabolizing enzyme
- Does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- No teratogenic effects in animal studies
- Excretion in milk not studied
- Consideration for discontinuation of breastfeeding if essential
Precautions & Warnings
- Symptomatic response does not preclude the presence of gastric malignancy
- Instructions for patients with difficulty swallowing capsules
- Use of antacids while taking Esotem
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- No overall differences in safety and efficacy observed between the elderly and younger individuals
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- Pharmacokinetics not expected to be altered in patients with renal impairment
Overdose Effects
- Acute toxicity in rats
- No specific antidote known
- Symptomatic and supportive treatment recommended
Storage Conditions
- Store at a temperature not exceeding 30°C
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Image of Chemical Structure
Commonly Asked Questions
- Description of Esotem 40 mg Capsule
- Uses of Esotem 40 mg Capsule
- Side effects of Esotem 40 mg Capsule
- Usage during pregnancy and breastfeeding