Temtrix 1 gm/vial (IM Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Team pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a third generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It interferes with the synthesis of the bacterial cell wall and has a long plasma elimination half-life of about 6 to 9 hours.
Dosage
- Usual dose for adults: 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum dose for adults: 4 gm/day
- Usual dose for infants and children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Maximum dose for infants and children: 2 gm/day
- Duration of therapy: 4 to 14 days (or longer in complicated infections)
Administration
- Preparation of Solutions for Intramuscular Injection: 250 mg or 500 mg Ceftriaxone dissolved in Lidocaine HCI 1% injection
- Preparation of Solutions for Intravenous Injection: 250 mg, 500 mg, 1g, or 2g Ceftriaxone dissolved in Water for injection
- Injection should be administered over 2-4 minutes for Intramuscular or Intravenous injection, or over 30 minutes for tubing infusion
Interaction
No drug interactions reported
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects
- Cutaneous reactions
- Hematologic reactions
- Hepatic reactions
- CNS reactions
- Local phlebitis following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established, caution advised during lactation
Precautions & Warnings
- Risk of anaphylactic shock
- Potential gallbladder sludge detection
- Regular blood picture checks during prolonged treatment
Use in Special Populations
Avoid use in premature and newborn neonates (up to 28 days of age)
Overdose Effects
No specific antidote, treatment should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children