Losap 50 mg (Tablet)
Unit Price: ৳ 5.97 (30's pack: ৳ 179.10)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Doctors chemical works ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily if 50 mg once daily is inadequate
- Different dosage for patients upto 75 years and over 75 years
Interaction
- Reduction in levels of active metabolite by Rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increased serum potassium with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Pregnant women
- Hypersensitivity to any component
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects: fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus during second or third trimesters
- Potential excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death in second and third trimesters
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for patients with moderate to severe renal impairment or on dialysis
- Lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children