Mtrex 10 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methotrexate |
| Company | Techno drugs ltd |
| Also available as |
Indications
- Treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole
- Treatment of acute lymphoblastic leukemia
- Treatment of non-Hodgkin’s lymphomas
- Treatment of breast cancer
- Treatment of head and neck cancers
- Treatment of mycosis fungoides (cutaneous T-cell lymphoma)
- Treatment of lung cancer
- Management of severe, active rheumatoid arthritis in adults
- Management of polyarticular-course juvenile rheumatoid arthritis in children
- Control of severe, recalcitrant, disabling psoriasis
Pharmacology
- Inhibition of dihydrofolic acid reductase
- Interference with DNA synthesis and repair
- Interference with cellular replication
- Selective sensitivity in malignant cells and actively proliferating tissues
- Control of psoriatic process
Dosage
- Oral or intramuscular administration for neoplastic diseases
- Induction and maintenance doses for acute lymphoblastic leukemia
- Dosing for lymphoma and mycosis fungoides
- Intravenous administration for breast and head and neck cancers
- Weekly single doses for rheumatoid arthritis and psoriasis
Administration
Best taken on an empty stomach and may be taken with meals to reduce gastrointestinal discomfort
Interaction
- Interaction with NSAIDs
- Toxicity interactions with salicylates, phenylbutazone, phenytoin, and sulfonamides
- Monitoring and caution with cisplatin and mercaptopurine
- Decreased intestinal absorption with certain antibiotics
- Decreased response to folic acid in vitamin preparations
- Possible bone marrow suppression with trimethoprim/sulfamethoxazole
Contraindications
- Alcoholism, alcoholic liver disease, or other chronic liver disease
- Immunodeficiency syndromes
- Pre-existing blood dyscrasias
- Hypersensitivity to methotrexate
- Pregnancy and nursing
Side Effects
- Ulcerative stomatitis
- Leukopenia
- Nausea and abdominal distress
- Malaise and fatigue
- Chills and fever
- Impairment of fertility
- Menstrual dysfunction
Pregnancy & Lactation
US FDA Pregnancy Category X, contraindicated in nursing mothers
Precautions & Warnings
- Avoid use of formulations and diluents containing preservatives for certain therapies
- Close monitoring for toxic effects
- Consideration of leucovorin calcium for adverse reactions
- Caution and increased alertness for recurrence of toxicity with reinitiated therapy
- Evaluation of liver function test abnormalities
- Consideration of folate deficiency as an increased toxicity factor
Use in Special Populations
- Pediatric patients: Caution in use alone or in combination with other drugs
- Geriatric patients: Closely monitor early signs of hepatic, bone marrow, and renal toxicity
Overdose Effects
Leucovorin indicated to diminish toxicity and counteract overdosage effects
Therapeutic Class
Antidote preparations, Immunosuppressant
Storage Conditions
Temperature not exceeding 30°C, protect from light and moisture