Losar 50 mg (Tablet)
Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Nipa pharmaceuticals ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- If inadequate, 25 mg twice daily is recommended
- Total daily dose ranges from 25 mg to 100 mg
- Adjusted dosage for patients above 75 years
- Administered once or twice daily
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics, potassium supplements or salt substitutes containing potassium may lead to increases in serum potassium
- Attenuation by non-steroidal anti-inflammatory drug indomethacin
- Increased risk of renal impairment with other specific drugs
Contraindications
- Pregnant women
- Hypersensitivity to any component
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects like fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk increases if administered during the second or third trimesters
- Not known whether excreted in human milk
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Use caution in patients with intravascular volume depletion
- Consider lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children