SB-Sovir 400 mg (Tablet)
Unit Price: ৳ 600.00 (1 x 4: ৳ 2,400.00)
Strip Price: ৳ 2,400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sofosbuvir |
| Company | Sunman birdem pharma ltd |
Indications
- Treatment of chronic hepatitis C (CHC) infection
- Established efficacy in subjects with HCV genotype 1, 2, 3 or 4 infection
- Treatment response varies based on baseline host and viral factor
Pharmacology
- Sofosbuvir is a nucleotide analog inhibitor
- Inhibits HCV NS5B RNA-dependent RNA polymerase
- Acts as a chain terminator for viral replication
Dosage & Administration
- One 400 mg tablet taken once daily with or without food
- Recommended combination therapy for different genotypes
- Considerations for patients with hepatocellular carcinoma and liver transplantation
Interaction
- Reduced therapeutic effect with potent P-gp inducers and certain drugs
- Potential for serious symptomatic bradycardia when co-administered with amiodarone
Contraindications
- Contraindicated in pregnant women and male partners of pregnant women
- Applicable contraindications when used in combination with Ribavirin or Peginterferon alfa/Ribavirin
Side Effects
- Common adverse events include fatigue, headache, nausea, insomnia, anemia, pruritus, and more
Pregnancy & Lactation
- Pregnancy Category B
- No adequate and well-controlled studies in pregnant women
- Unknown presence in human breast milk
Precautions & Warnings
- Potential for serious symptomatic bradycardia with amiodarone co-administration
- Cardiac monitoring recommended in certain patients
Use in Special Populations
- Safety and effectiveness in children under 18 not established
- Response rates observed in subjects aged 65 and over were similar to younger subjects
Overdose Effects
- The highest recommended dose is a single 1200 mg tablet
- No specific antidote available
- Treatment consists of general supportive measures and monitoring
Therapeutic Class
- Hepatic viral infections (Hepatitis C)
Storage Conditions
- Keep out of reach of children
- Store in a cool, dry place
- Protect from light