Losarcar 50 mg (Tablet)
Unit Price: ৳ 6.00 (30's pack: ৳ 180.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Medimet pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Angiotensin II receptor blocker
- Reduces vasoconstriction
- Binds to AT1 receptor
- Reduces release of aldosterone
Dosage & Administration
- Usual starting dose of 50mg daily
- 25mg twice daily if inadequate effect
- Lower starting dose for patients over 75 years
- Total daily dose ranges from 25mg to 100mg
Interactions
- Reduced levels with rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Possible increase in serum potassium with potassium-sparing diuretics
- Attenuated effect with indomethacin
- Increased risk of renal impairment when combined with certain drugs
Contraindications
- Contraindicated in pregnant women
- Hypersensitivity to any component
- Not to be administered with Aliskiren in diabetic patients
Side Effects
- Mild and transient side effects
- Common side effects: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects: fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy category D
- Risk increases in second or third trimester
- Decision should be made whether to discontinue nursing
Precautions & Warnings
- Reduces fetal renal function in pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Increased plasma concentration in cirrhotic patients
- Changes in renal function reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for patients with moderate to severe renal impairment or on dialysis
- Consider lower dose for patients with hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children