Doperon 10 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | United pharmaceuticals ltd |
| Also available as |
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Functional nausea and vomiting
- Parkinson's disease
- Radiological studies
Symptoms
- Epigastric sense of fullness
- Abdominal distension
- Upper abdominal pain
- Eructation
- Flatulence
- Early satiety
- Nausea
- Vomiting
- Heartburn
- Regurgitations of gastric contents
Pharmacology
- Dopamine antagonist
- ChemoreceptorTrigger Zone (CTZ) blocker
- Gastroprokinetic action
- Promotes gastrointestinal motility
- Enhances gastric emptying
- Regulates pyloric contraction
- Increases esophageal peristalsis
Dosage & Administration
- Adult dose: 10-20 mg every 6-8 hours
- Children's dose based on body weight
- Rectal administration available
- Maximum daily dose: 80 mg
- Treatment duration: Up to 12 weeks
Interactions
- Anticholinergic drugs antagonize effects
- Avoid concomitant use with antacids
- Metabolized via CYP3A4 pathway
- Inhibitors may increase plasma levels
- No influence on neuroleptics
- Suppression of unwanted effects of dopaminergic agonists
Contraindications
- Hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction
- Prolactin releasing pituitary tumor
Side Effects
- Transient intestinal cramps
- Extrapyramidal phenomena
- Increase in plasma prolactin level
- Rare allergic reactions
- Neurological side effects in infants
Pregnancy & Lactation
- Use in first trimester justified by benefit
- Excretion in breast milk
- Lower concentration in breast milk than plasma
Precautions & Warnings
- Caution in children for extrapyramidal reactions
- Caution in hepatic impairment
Use in Special Populations
- Caution in infants under 1 year
- Caution in liver disorders
- Caution in severe renal insufficiency
Overdose Effects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular formula: C22H24ClN5O2