Pizzi 15 mg (Tablet)

Indications

• Adjunct to diet and exercise for glycaemic control in type II diabetes (NIDDM)
• Monotherapy and combination therapy with sulphonylurea, Metformin, or Insulin

Pharmacology

• Belongs to thiazolidinediones class
• Depends on Insulin for mechanism of action
• Decreases Insulin resistance in periphery and liver
• Improves abnormality in lipid metabolism

Dosage & Administration

• Can be taken once daily without regard to meals
• Initiate at 15 mg or 30 mg once daily for monotherapy
• Maximum recommended daily dose is 45 mg
• Consider combination therapy for inadequate response

Interaction

• Reduces plasma concentration of oral contraceptive containing ethinyl oestradiol and norethindrone

Contraindications

• Known hypersensitivity to any of its components

Side Effects

• Incidence and types of adverse events reported in clinical trials
• Includes upper respiratory tract infection, headache, sinusitis, myalgia, tooth disorder, pharyngitis

Pregnancy & Lactation

• Use during pregnancy if benefit justifies potential risk to the foetus
• Not known if secreted in human milk, should not be administered to lactating women

Precautions & Warnings

• Exerts antihyperglycaemic effect only in presence of Insulin
• Not suitable for Type 1 diabetes or diabetic ketoacidosis treatment
• Use with caution in combination antidiabetic therapy and hepatic insufficiency
• Regular monitoring of liver enzymes

Therapeutic Class

• Thiazolidinedione Group

Storage Conditions

• Store at 25°C

Related Brands

• Uzone 15 mg (Tablet) - union-pharmaceuticals-ltd