Doxpro 100 mg (Capsule)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxycycline hydrochloride |
| Company | Premier pharmaceuticals ltd |
Title
- Doxpro (Doxycycline Hydrochloride)
Category
- Antibiotic
- Medicine
- Pharmaceutical
Description
- Highly active broad-spectrum antibiotic of tetracycline group
- Effective against a wide range of Gram-positive and Gram-negative bacteria
- Used as an alternate to penicillin in the treatment of gonorrhea and syphilis
- Main mechanism of action on protein synthesis
Indications
- Treatment of respiratory tract infections like pneumonia, influenza, sinusitis, bronchitis, tonsillitis, and tracheitis
- Treatment of gastrointestinal tract infections including cholera, traveler's diarrhea, shigella dysentery, and acute intestinal amebiasis
- Treatment of chlamydial infections such as lympho-granuloma venereum, psittacosis, and trachoma
- Treatment of sexually transmitted diseases like non-gonococcal urethritis, acute pelvic inflammatory disease, gonorrhea, syphilis, pyelonephritis, and cystitis
- Treatment of other infections like impetigo, furunculosis, inclusion conjunctivitis, brucellosis, tularemia, cellulitis, acne, and Q-fever
Pharmacology
- Semisynthetic tetracycline antibiotic with broad spectrum activity
- Primarily a bacteriostatic antibiotic
- More active against Staphylococcus aureus and Nocardia
- Active against penicillin-resistant strains of Staphylococcus aureus and certain Gram-negative strains of E. coli, Proteus mirabilis, and Klebsiella
- Active against Haemophilus influenzae, H. ducreyi, Actinomyces, Brucella, Vibrio cholerae, Nocardia, Chlamydia, Mycoplasma, Rickettsiae, and spirochetes like Borellia recurrentis, Treponema pallidum, and Treponema pertenue
- Active against Plasmodium falciparum
Dosage
- Usual dose: 200 mg on the first day, then 100 mg daily for 7-10 days
- Severe infections (including refractory urinary tract infections): 200 mg daily for 10 days
- Acne: 100 mg daily
- Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease)
Administration
- Capsules should be swallowed whole with plenty of fluid during meals while sitting or standing
Interactions
- Absorption impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations
- Absorption impaired by bismuth salicylate
- Half-life decreased by barbiturates, carbamazepine, and phenytoin
- Concurrent use with oral contraceptives may render them less effective
- Patients on anticoagulant therapy may require downward adjustment of their dosages
- Avoid giving tetracyclines in conjunction with penicillin
Contraindications
- Hypersensitivity to any tetracyclines
- Children under 8 years of age
- Pregnant women
- Lactating mothers
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Skin rashes
- Hemolytic anemia
- Eosinophilia
Pregnancy & Lactation
- Avoided in pregnant women due to the risk of staining and effect on bone growth in the fetus
- Enter breast milk, so mothers taking these drugs should not breastfeed their child
Precautions & Warnings
- Avoid use during tooth development (last half of pregnancy, infancy, and childhood to the age of 8 years) as it may cause permanent discoloration of teeth
Therapeutic Class
- Tetracycline group of drugs
Storage Conditions
- Keep all medicines out of reach of children
- Store in a cool and dry place, protected from light