Pergel 20 mg (Tablet (Enteric Coated))

Indications

• Relief from chronic heartburn symptoms and other symptoms associated with GERD
• Healing of erosive esophagitis
• Maintenance of healing of erosive esophagitis
• Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
• Zollinger-Ellison Syndrome
• Acid-related Dyspepsia
• Duodenal & Gastric ulcer

Pharmacology

• Proton pump inhibitor
• Suppression of gastric acid secretion
• Specific inhibition of H+/K+-ATPase in the gastric parietal cell
• Enteric-coated pellet formulation of esomeprazole magnesium
• Metabolized in the liver by the cytochrome P450 enzyme system
• Extensively metabolized by CYP2C19 and CYP3A4
• Peak plasma levels occur at approximately 1.5 hours after oral administration
• Plasma protein binding is constant over the concentration range of 2-20 mmol/L

Dosage

• Various dosage forms including oral capsules, oral suspension, IV injection, and IV infusion
• Different doses for different indications such as esophagitis, symptomatic GERD, Helicobacter pylori eradication, Zollinger-Ellison Syndrome, Dyspepsia, Duodenal & Gastric ulcer
• Different dosages for adult and pediatric patients
• Different routes of administration for different patient groups

Administration

• Tablet or capsule should be swallowed whole and taken one hour before a meal
• Oral suspension should be taken with a specific amount of water and administered through a nasogastric or gastric tube
• IV Injection solution for injection preparation and administration guidelines

Interaction

• Metabolism in the liver by CYP2C19 and CYP3A4
• Inhibition of gastric acid secretion, potential interference with drug absorption
• No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin

Contraindications

• Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

• Headache
• Diarrhoea
• Nausea
• Flatulence
• Abdominal pain
• Constipation
• Dry mouth
• No difference in types of related adverse events seen during maintenance treatment up to 12 months compared to short-term treatment

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• No teratogenic effects observed in animal studies
• Lack of information on excretion of esomeprazole in milk

Precautions & Warnings

• Symptomatic response to therapy does not preclude the presence of gastric malignancy
• Guidelines for administration in patients who have difficulty swallowing capsules
• Use of antacids while taking the medication

Use in Special Populations

• Safety and effectiveness in pediatric patients have not been established
• No overall differences in safety and efficacy observed between the elderly and younger individuals
• No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
• Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

• Signs of acute toxicity observed in rats at high doses
• No specific antidote known
• Treatment should be symptomatic and supportive

Storage Conditions

• Store at a temperature not exceeding 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C17H19N3O3S
• Chemical structure illustration provided

Common Questions about Pergel 20 mg Tablet

• Overview of Pergel 20 mg Tablet as a proton pump inhibitor (PPI)
• Multiple uses including treatment for GERD, ulcers, and preventing erosive esophagitis recurrence
• Information on common side effects, pregnancy and breastfeeding, onset of action, and quick tips for usage

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