Losaron 50 mg (Tablet)
Unit Price: ৳ 5.00 (30's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Amico laboratories ltd |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily if 50 mg once daily is inadequate
- Consider 25 mg once daily for patients with intravascular volume-depletion
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily for patients over 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics, potassium supplements or salt substitutes containing potassium may lead to increases in serum potassium
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with combined use of ACE-inhibitor, angiotensin receptor antagonist, anti-inflammatory drug, and thiazide diuretic
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Avoid administration with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects may include fatigue, oedema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk increases if administered during second or third trimesters of pregnancy
- Unknown excretion in human milk, potential for adverse effects on the nursing infant
Precautions & Warnings
- Reduce fetal renal function and increase fetal and neonatal morbidity and death when used in second and third trimesters of pregnancy
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Lower dose recommended for patients with a history of hepatic impairment
- Use with caution in patients with intravascular volume depletion
- Contraindicated in pregnancy and in patients hypersensitive to losartan
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children