Premier's Azithromycin 500 mg (Tablet)

Unit Price: ৳ 30.00 (6's pack: ৳ 180.00)

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Premier pharmaceuticals ltd
Also available as
Azithromycin 200 mg suspension

Title

  • Premier's Azithromycin 500 mg Tablet

Categories

  • Medicine
  • Pharmaceuticals

Description

  • Azithromycin for oral suspension and injection
  • Effective against susceptible organisms
  • Indicated for various respiratory and skin infections
  • Bacteriostatic levels maintained in infected tissue
  • No effect on lipid solubility
  • Interferes with microbial protein synthesis
  • Active against various aerobic and anaerobic gram-positive and gram-negative microorganisms
  • Recommended dosage for adults and children
  • Reconstitution procedure for suspension
  • Interaction with antacids, carbamazepine, cyclosporine, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, and terfenadine
  • Contraindications in hypersensitive patients and those with hepatic diseases
  • Low incidence of side effects, including gastrointestinal discomfort and allergic reactions
  • Pregnancy category B, caution in nursing women
  • Precautions in renal and hepatic impairment
  • No data on overdosage
  • Storage conditions in a dry place away from light and heat
  • Chemical structure with molecular formula C38H72N2O12
  • Common questions and answers about the product

Dimensions

  • Suspension reconstitution process

Color Options

  • None

Functions

  • Prevention of essential protein synthesis in bacteria
  • Treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections

Materials

  • None

Technical Specifications

  • Absorption: Greater on an empty stomach, time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms
  • Half-life: 68 hours for a single 500 mg dose, prolonged terminal half-life due to extensive uptake and release of the drug from tissues
  • Elimination: Approximately 6% of the administered dose appears as unchanged drug in urine
  • Microbial Action: Binds to the 50S ribosomal subunit of susceptible microorganisms, interfering with microbial protein synthesis
  • Recommended Dosage:
    • Oral Adult:
      • 500 mg once daily for 3 days
      • 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days
    • Oral Children:
      • 10 mg/kg body weight once daily for 3 days for child over 6 months
      • 200 mg for 3 days if body weight is 15-25 kg
      • 300 mg for 3 days if body weight is 26-35 kg
      • 400 mg for 3 days if body weight is 36-45 kg
    • Injection Adult (IV Infusion):
      • 500 mg as a single daily dose by the intravenous route for at least two days
      • 500 mg for the treatment of pelvic inflammatory disease by the intravenous route for one or two days

Design Elements

  • Chemical structure
  • Suspension reconstitution procedure

Usability Features

  • Oral administration
  • Caution in timing of consumption with meals and antacids
  • No effect on driving or machine operation

Interaction

  • With antacids, carbamazepine, cyclosporine, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, and terfenadine

Contraindications

  • Hypersensitivity to Azithromycin or macrolide antibiotics
  • Co-administration of ergot derivatives
  • Hepatic diseases

Side Effects

  • Gastrointestinal discomfort
  • Allergic reactions
  • Reversible elevations in liver transaminases
  • Cholestatic jaundice
  • Mild reductions in neutrophil counts
  • Reversible hearing impairment with higher doses for prolonged periods

Pregnancy & Lactation

  • Category: B
  • Safety: Demonstrated no harm in animal reproduction studies
  • Caution: Use during pregnancy only if adequate alternatives are not available, caution in nursing women

Precautions & Warnings

  • Rare serious allergic reactions reported
  • Long period of observation and treatment required in some cases

Use in Special Populations

  • Renal Impairment:
    • No dose adjustment needed in patients with mild impairment
    • Caution in using Azithromycin with more severe renal impairments
  • Hepatic Impairment:
    • Not to be used in patients with hepatic disease
  • Effects on ability to drive and use machines: No evidence of any effect

Overdose Effects

  • No data available
  • Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C38H72N2O12
  • Image: https://medex.com.bd/storage/res/g-res-100-azithromycin-dihydrate-chemical-structure-tFo4BQqfsRzQwcODCGo2.svg

Common Questions

  • What is it: Premier's Azithromycin 500 mg Tablet is an antibiotic that prevents the synthesis of essential proteins required by bacteria
  • Uses: Treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections
  • Side Effects: Diarrhea, dry or scaly skin, abdominal pain, difficult or painful urination, vomiting, fever, acid or sour stomach, aggression or anger, excessive air or gas in the stomach, heartburn
  • Storage and Disposal: Keep in a cool dry place and its original packaging, make sure it remains unreachable to children and pets, consult a doctor for further uses
  • Cause diarrhea: Yes, it can cause diarrhea due to its impact on helpful bacteria in the stomach or intestine

Related Brands