Losarpex 50 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Apex pharmaceuticals ltd |
Indications
- Lowering high blood pressure
- Treatment of hypertension
- Delaying progression of renal disease in hypertensive type-2 diabetics with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor found in various tissues
- Reduces vasoconstriction and release of aldosterone responsible for hypertension
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily for most patients
- Option to use alone or in combination with other antihypertensive agents
- Different dosages for patients with intravascular volume-depletion
Interactions
- Reduced levels with Rifampicin and fluconazole
- Potentiation of antihypertensive effects with concomitant use of hydrochlorothiazide
- Risk of increased serum potassium with concomitant use of potassium-sparing diuretics or supplements
Contraindications
- Contraindicated in pregnant women
- Hypersensitivity to any component of the product
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects: fatigue, oedema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk increases if administered during the second or third trimesters of pregnancy
- Unknown excretion in human milk
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death in second and third trimesters of pregnancy
- Possible symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for patients with moderate to severe renal impairment
- Lower dose consideration for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children