Losart 25 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor
- Reduces vasoconstriction
- Reduces aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50mg once daily
- May be used alone or in combination with other antihypertensive agents
- Total daily dose ranges from 25mg to 100mg
- Different dosage for patients under 75 years and over 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use of Losart and hydrochlorothiazide may lead to potentiation of antihypertensive effects
- Concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes may lead to increase in serum potassium
- Attenuation by non-steroidal anti-inflammatory drug indomethacin
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Dizziness
- Diarrhea
- Nasal congestion
- Cough
- Upper respiratory infection
- Fatigue
- Oedema
- Abdominal pain
- Chest pain
- Nausea
- Headache
- Pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus increases if administered during second or third trimesters
- Not known whether excreted in human milk
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Plasma concentration significantly increased in cirrhotic patients
- Renal failure reported in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment
- For patients with moderate to severe renal impairment, a lower starting dose is recommended
- Use in patients with intravascular volume depletion
- Use in hepatic impairment
- Lower dose should be considered for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children