Bioxon 500 mg/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Benham pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. It is not metabolized in the body and is excreted unchanged in the urine and feces; it is highly protein bound (95%).
Dosage
- The usual dose for adults is 1 to 2 gm by intravenous or intramuscular administration once a day or in equally divided doses twice a day
- The maximum adult dose is 4 gm/day
- For uncomplicated gonococcal infections, the dose is 250 mg IM as a single dose
- For surgical prophylaxis, the dose is 1 g IV as a single dose 30 to 120 minutes before surgery
- The usual dose for infants and children (01 month or older) is 50 to 75 mg/kg intravenous or intramuscular administration once a day or in equally divided doses twice a day
- The maximum dose for children is 2 gm/day
Administration
- For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection
- For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection or 1 g/2 g Ceftriaxone should be dissolved in Water for injection
Interaction
No drug interactions have been reported
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- Gastro-intestinal effects including diarrhea, nausea, and vomiting, stomatitis, and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema, and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia, and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, and dizziness
- Local phlebitis following intravenous administration
Pregnancy & Lactation
Its safety in human pregnancy has not been established. Therefore, it should not be used in pregnancy unless absolutely indicated. Low concentrations of Ceftriaxone are excreted in human milk. Caution should be exercised when Ceftriaxone is administered to a lactating mother
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid
- Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
- During prolonged treatment, the blood picture should be checked at regular intervals
Use in Special Populations
Bioxon must not be given to neonates if the neonate is premature and newborn (up to 28 days of age)
Overdose Effects
There is no specific antidote. Treatment of overdosage should be symptomatic
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30º C), away from light & moisture. Keep out of the reach of children