Bioxon 1 gm/vial (IM Injection)

1 gm vial: ৳ 185.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Benham pharmaceuticals ltd
Also available as
Bioxon 500 mg injection Bioxon 500 mg injection Bioxon 1 gm injection Bioxon 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • High degree of stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body

Dosage

  • 1 to 2 gm by intravenous or intramuscular administration once a day for adults
  • 50 to 75 mg/kg intravenous or intramuscular administration once a day for infants and children (01 month or older)
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared

Administration

  • Preparation of Solutions for Intramuscular / Intravenous Injections using Lidocaine HCI 1% injection or Water for injection
  • Injection should be administered over 2-4 minutes

Interaction

No drug interactions have been reported

Contraindications

Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely following intravenous administration

Pregnancy & Lactation

Safety in human pregnancy has not been established, caution in lactating mother

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder, reversible on discontinuation or completion of Bioxon therapy
  • Regular intervals blood picture check during prolonged treatment

Use in Special Populations

Must not be given to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote, treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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