Losart 50 mg (Tablet)
Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor
- Reduces vasoconstriction
- Reduces aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg
- Recommended 25 mg twice daily if 50 mg once daily is inadequate
- Lower starting dose of 25 mg for patients over 75 years
- Total daily dose ranges from 25 mg to 100 mg
- No initial dosage adjustment for patients upto 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use of losartan and hydrochlorothiazide may lead to potentiation of antihypertensive effects
- Concomitant use of potassium-sparing diuretics may lead to increases in serum potassium
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Pregnant women
- Hypersensitivity to any component
- Concurrent use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other: fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to fetus during second or third trimesters
- Consideration for discontinuing nursing if excreted in human milk
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death during second and third trimesters
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose for patients with a history of hepatic impairment
- Caution with other drugs affecting renin-angiotensin-aldosterone system
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children