Bioxon 2 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Benham pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Like other cephalosporins and penicillins, Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases. Its relatively long plasma elimination half-life of about 6 to 9 hours makes single or once-daily dosage appropriate for most patients.
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day
- Maximum dose: 4 gm/day
- Uncomplicated gonococcal infections: 250 mg IM as a single dose
- Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
- Infants and Children: 50 to 75 mg/kg intravenous or intramuscular administration once a day
- Duration of therapy: 4 to 14 days
Administration
Preparation of Solutions for Intramuscular / Intravenous Injections: For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection. For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection. The injection should be administered over 2-4 minutes. Before starting treatment through Ceftriaxone injection, patient tolerance test should be checked by administration of a test dose.
Interaction
No drug interactions have been reported.
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.
Side Effects
- Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
- Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
- Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis occurs rarely following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy has not been established. Ceftriaxone is excreted in human milk thus caution should be exercised when administered to a lactating mother.
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Gallbladder abnormalities reversible on discontinuation or completion of therapy
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
Bioxon must not be given to neonates if premature and newborn (up to 28 days of age).
Overdose Effects
There is no specific antidote. Treatment of overdosage should be symptomatic.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30 C), away from light & moisture. Keep out of the reach of children.