Esoben MUPS 20 mg (MUPS Tablet)

Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Benham pharmaceuticals ltd

Title

  • Esoben MUPS 20 mg Tablet

Categories

  • Medicine
  • Health
  • Pharmaceutical

Description

  • MUPS is abbreviation for Multiple-Unit Pellet System
  • Ensures greater bioavailability
  • Ensures uniform emptying of micro pellets from stomach into small intestine
  • Facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax
  • Ensures lesser possibility of dose dumping
  • Combination of fast acting and sustained action
  • Once daily dosing
  • Ensures better and more uniform drug absorption
  • Minimizes fluctuation in plasma concentration of drug
  • Rapid and uniform gastric emptying
  • Uniform drug dissolution of pellets in the gastrointestinal tract
  • Consistent and controlled pharmacological action
  • Reduction in inter- and intra-subject variability in drug absorption

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • 133.333 mg (15%w/w) of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole
  • 266.67 mg (15% w/w) of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole

Pharmacology

  • Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system

Dosage

  • 40 mg once daily for 4 weeks (Adults)
  • 20 mg once daily (Adults)
  • 20 mg once daily for 4-8 weeks (Adults)
  • 20 mg twice daily for 7 days (Adults)
  • 40-80 mg twice daily (Adults)
  • 10 mg once daily for 8 weeks (Children 1-11 years)
  • 10 mg or 20 mg once daily for 8 weeks (Children 1-11 years)

Administration

  • Tablets should be swallowed whole with liquid
  • Can be dispersed in half a glass of non-carbonated water

Interaction

  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • No clinically relevant interactions with drugs metabolized by these CYP enzymes
  • May interfere with the absorption of drugs where gastric pH is important

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • Caution advised

Precautions & Warnings

  • Use carefully if the patient has severe liver dysfunction and severe renal impairment
  • Slightly increases the risk of hip, wrist and spine fracture over a period of more than one year

Storage Conditions

  • Store in a cool & dry place below 25°C
  • Protect from light
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions

  • Multiple uses including treating GERD and ulcers
  • Common side effects include headache, diarrhea, nausea
  • Caution advised for pregnant and breastfeeding individuals

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