Midorest 15 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Midazolam |
| Company | Benham pharmaceuticals ltd |
| Also available as |
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Description
Sleep-inducing agent characterized by a rapid onset and short duration of action. Also exerts anxiolytic, anticonvulsant, and muscle-relaxant effect.
Pharmacology
The actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Benzodiazepines increase the activity of GABA, thereby producing a sedating effect, relaxing skeletal muscles, inducing sleep, anesthesia, and amnesia.
Dosage & Administration
- Oral dosage for adults: 7.5-15 mg daily
- Elderly and debilitated patients: 7.5 mg
- Premedication: 15 mg 30-60 minutes before the procedure
- Intravenous administration for various procedures
- Intramuscular administration for adults and children
- Rectal administration for preoperative sedation in children
Interaction
Can enhance the central sedative effect of various drugs
Contraindications
Must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, and with known hypersensitivity to benzodiazepines or any component of the product
Side Effects
Drowsiness, confusion, fatigue, headache, muscle weakness, fluctuations in vital signs including respiratory depression, apnea, variations in blood pressure, and pulse rate.
Pregnancy & Lactation
Avoid during pregnancy unless there is no safer alternative, not recommended for breastfeeding mothers
Precautions & Warnings
Midorest IV should be administered very slowly
Overdose Effects
Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression, and apnea. Effects can be controlled with benzodiazepine antagonist flumazenil
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
Protect from light and moisture, store in a cool and dry place. Keep out of the reach of children.