Midorest 15 mg (Tablet)

Unit Price: ৳ 15.00 (2 x 10: ৳ 300.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Midazolam
Company Benham pharmaceuticals ltd
Also available as

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Description

Sleep-inducing agent characterized by a rapid onset and short duration of action. Also exerts anxiolytic, anticonvulsant, and muscle-relaxant effect.

Pharmacology

The actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Benzodiazepines increase the activity of GABA, thereby producing a sedating effect, relaxing skeletal muscles, inducing sleep, anesthesia, and amnesia.

Dosage & Administration

  • Oral dosage for adults: 7.5-15 mg daily
  • Elderly and debilitated patients: 7.5 mg
  • Premedication: 15 mg 30-60 minutes before the procedure
  • Intravenous administration for various procedures
  • Intramuscular administration for adults and children
  • Rectal administration for preoperative sedation in children

Interaction

Can enhance the central sedative effect of various drugs

Contraindications

Must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, and with known hypersensitivity to benzodiazepines or any component of the product

Side Effects

Drowsiness, confusion, fatigue, headache, muscle weakness, fluctuations in vital signs including respiratory depression, apnea, variations in blood pressure, and pulse rate.

Pregnancy & Lactation

Avoid during pregnancy unless there is no safer alternative, not recommended for breastfeeding mothers

Precautions & Warnings

Midorest IV should be administered very slowly

Overdose Effects

Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression, and apnea. Effects can be controlled with benzodiazepine antagonist flumazenil

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

Protect from light and moisture, store in a cool and dry place. Keep out of the reach of children.

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