Losatan 50 mg (Tablet)

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)

Strip Price: ৳ 80.00

Medicine Details

Category	Details
Generic	Losartan potassium
Company	Popular pharmaceuticals ltd
Also available as	Losatan 25 mg tablet

Hypertension
Renal Protection in Type-2 Diabetic Patients with Proteinuria
Treatment of hypertension alone or in combination with other antihypertensive agents

Non-peptide orally active angiotensin II receptor blocker
Binds to the AT1 receptor found in vascular smooth muscle, adrenal gland, kidneys and the heart
Reduces vasoconstriction and the release of aldosterone responsible for hypertension

Usual starting and maintenance dose of 50 mg once daily for most patients
25 mg twice daily recommended if 50 mg once daily is inadequate
Starting dose of 25 mg once daily for patients with intravascular volume-depletion
Total daily dose ranges from 25 mg to 100 mg
Lower starting dose of 25 mg once daily recommended for patients over 75 years

Rifampicin and fluconazole reduce levels of active metabolite of Losatan
Concomitant use of Losatan and hydrochlorothiazide may lead to potentiation of the antihypertensive effects
Concomitant use of potassium-sparing diuretics, potassium supplements or salt substitutes may lead to increases in serum potassium
The antihypertensive effect of losartan may be attenuated by the non-steroidal anti-inflammatory drug indomethacin
Concomitant use of ACE-inhibitor, angiotensin receptor antagonist, an anti-inflammatory drug and a thiazide diuretic at the same time increases the risk of renal impairment

Mild and transient side effects
Common side effects: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
Other side effects: fatigue, oedema, abdominal pain, chest pain, nausea, headache, pharyngitis

Pregnancy Category D
Risk to the fetus increases if administered during the second or third trimesters of pregnancy
Not known whether excreted in human milk, may have potential adverse effects on the nursing infant

Reduces fetal renal function and increases fetal and neonatal morbidity and death during the second and third trimesters of pregnancy
Symptomatic hypotension may occur in intravascularly volume-depleted patients
Significantly increased plasma concentration in cirrhotic patients
Changes in renal function including renal failure reported in renal impaired patients
Dosage adjustments necessary in patients with renal impairment or hepatic impairment
Caution in patients with intravascular volume depletion

No initial dosage adjustment necessary in patients with mild renal impairment
Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
Use caution in patients treated with high-dose diuretics
Lower dose should be considered for patients with a history of hepatic impairment