Folita 5 mg (Tablet)
Unit Price: ৳ 9.00 (5 x 10: ৳ 450.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Square pharmaceuticals plc |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
- Treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome
Composition
- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Metabolite and active form of folic acid
- Cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids
Dosage & Administration
- Calcium folinate rescue treatment regimen
- Dose of methotrexate triggering Folinic Acid administration
- Dosage regimens for Folinic Acid
Interaction
- Counteracting antiepileptic effect of phenobarbitone, phenytoin and primidone
- Caution during concurrent administration with fluoropyrimidine
Contraindications
- Hypersensitivity to calcium folinate or any other components
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Use in pregnant women if benefit justifies potential risk to the fetus
- Caution during administration to nursing mothers
Precautions & Warnings
- Use with methotrexate or 5-FU under the direct supervision of a clinician experienced in cancer chemotherapeutic agents
- Treatment of inadvertent overdosage of a folic acid antagonist
- Prompt excretion measures for methotrexate
Overdose Effects
- Excessive amounts nullifying the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
- Appropriate supportive care for overdosage
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Store below 30°C
- Keep away from light
- Keep out of the reach of children