Lospil 50 mg (Tablet)
Unit Price: ৳ 8.00 (50's pack: ৳ 400.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | The white horse pharmaceuticals ltd |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50mg
- May be used alone or in combination with other antihypertensive agents
- Total daily dose ranges from 25mg to 100mg
- Different dosage recommendations for patients below and above 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics, potassium supplements, or salt substitutes may lead to increases in serum potassium
- Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drug indomethacin
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus increases if administered during second or third trimesters
- Unknown excretion in human milk, potential for adverse effects on nursing infant
Precautions & Warnings
- Reduction of fetal renal function and increase in fetal and neonatal morbidity and death in pregnancy
- Risk of symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
- Lower dose considered for patients with hepatic impairment
- Contraindicated in pregnancy and in patients who are hypersensitive to losartan
- Other drugs affecting renin-angiotensin-aldosterone system may increase blood urea and serum creatinine in certain patients
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children