Secrin M 1 mg+500 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (7 x 4: ৳ 252.00)
Strip Price: ৳ 36.00

Medicine Details

Category Details
Generic Glimepiride metformin
Company Square pharmaceuticals plc
Also available as
Secrin m 2 mg tablet

Indications and Usage

  • Adjunct to diet and exercise in type 2 diabetes mellitus patients
  • Inadequate glycemic control with monotherapy of glimepiride or metformin
  • Replacement of combination therapy of glimepiride and metformin

Pharmacology

  • Decreases blood glucose concentration
  • Stimulates the release of insulin from pancreatic beta cells
  • Improves sensitivity of beta cells to glucose stimulus
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin
  • Improves glucose uptake

Dosage

  • Governed by desired blood glucose level
  • Lowest effective dosage for desired metabolic control
  • Regular measurement of blood and urine glucose levels
  • Avoidance of larger doses to correct mistakes
  • Potential reduction of glimepiride requirements as treatment proceeds

Administration

  • Must be swallowed whole
  • Not to be crushed or chewed

Interaction

  • Metabolized by cytochrome P450 2C9 (CYP2C9)
  • Potentiation of blood-glucose-lowering effect with insulin and other oral antidiabetics
  • Weakening of blood-glucose-lowering effect with corticosteroids and diazoxide
  • Alcohol intake may influence blood-glucose-lowering action
  • Bile acid sequestrant (e.g., colesevelam) reduces glimepiride absorption

Contraindications

  • Hypersensitivity to glimepiride, metformin, or sulfonylureas
  • Pregnancy and breastfeeding for glimepiride
  • Acute metabolic acidosis or severe renal failure for metformin

Side Effects

  • Hypoglycemia
  • Temporary visual impairment
  • Gastrointestinal symptoms like nausea, vomiting, and diarrhea
  • Potential liver enzyme elevation and hepatitis
  • Hematological changes like thrombocytopenia and anemia

Pregnancy and Lactation

  • Avoidance during pregnancy for both glimepiride and metformin
  • Avoidance during lactation for glimepiride
  • Consideration of nursing discontinuation or metformin cessation in lactating mothers

Precautions and Warnings

  • Increased risk of hypoglycemia in initial weeks of treatment
  • Increased risk of hypoglycemia during illness or lifestyle changes
  • Caution in patients with G6PD-deficiency for glimepiride
  • Regular monitoring of thyroid-stimulating hormone (TSH) levels for metformin

Use in Special Populations

  • Insufficient data for pediatric use
  • Assessment of GFR before initiation and at least annual monitoring for renal impairment

Overdose Effects

  • Severe life-threatening hypoglycemia for glimepiride overdose
  • Potential lactic acidosis for high metformin doses
  • Pancreatitis in the context of a metformin overdose

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Cool and dry place, protected from light

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