Avloclav BID (400 mg+57.50 mg)/5 ml (Powder for Suspension)
50 ml bottle: ৳ 245.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amoxicillin clavulanic acid |
| Company | Aci limited |
| Also available as |
Indications
- Short-term treatment of bacterial infections at various sites
- Upper respiratory tract infections (e.g. tonsillitis, sinusitis, otitis media)
- Lower respiratory tract infections (e.g. acute and chronic bronchitis, pneumonia)
- Genito-urinary tract infections (e.g. cystitis, urethritis, pyelonephritis)
- Skin and soft tissue infections
- Bone and joint infections (e.g. osteomyelitis)
- Other infections (e.g. septic abortion, puerperal sepsis)
Composition
- Different tablet strengths: 375 mg, 625 mg, 1 gm
- Different film-coated tablet compositions
- Powder for Suspension composition
- Injection composition with specific Amoxicillin and Clavulanic Acid content
Pharmacology
- Broad spectrum bactericidal activity
- Contains Amoxicillin and Clavulanic Acid
- Inactivation of beta-lactamase enzymes
- Extended antibiotic spectrum
- Closely matched pharmacokinetics
Dosage
- Different dosages for adults and children
- Recommended dosage for various types and severity of infections
- Instructions for suspension, forte suspension, and IV injection
Administration
- Oral dosage form instructions
- IV injection administration instructions
- Utilization at the start of a meal for enhanced absorption
Interaction
- Prolongation of bleeding time and prothrombin time
- Potential reduction in efficacy of oral contraceptives
- Concomitant use of allopurinol
- Warning for patients
Contraindications
- History of Penicillin hypersensitivity
- Possible cross-sensitivity with other beta-lactam antibiotics
- Contraindication for patients with previous Co-amoxiclav or Penicillin-associated cholestatic jaundice
Side Effects
- Uncommon side effects such as diarrhea, colitis, indigestion, nausea, vomiting, candidiasis
- Rare side effects like hepatitis, cholestatic jaundice, urticarial and erythematous rashes
- Instances of erythema multiforme, Stevens-Johnson Syndrome, exfoliative dermatitis
- Potential angioedema and anaphylaxis
Pregnancy & Lactation
- Animal studies show no teratogenic effect
- Limited use in human pregnancy with no untoward effect
- Not recommended in pregnancy unless essential
- Detection of Amoxicillin in breast milk
Precautions & Warnings
- Careful use in patients on anticoagulation therapy or with severe hepatic dysfunction
- Dosage adjustment in moderate or severe renal impairment
- Maintenance of adequate fluid intake and urinary output during high-dose administration
Use in Special Populations
- Dose adjustment for patients with renal impairment
- Specific dose recommendations for various levels of impairment
- Caution and monitoring for patients with hepatic impairment
Overdose Effects
- Unlikelihood of overdose problems
- Possible gastrointestinal symptoms and electrolyte disturbance
- Potential removal from circulation by haemodialysis
Therapeutic Class
- Belongs to the category of broad spectrum penicillins
Reconstitution
- Details about IV injection reconstitution
- Restrictions on reconstitution or mixing with specific fluids
Storage Conditions
- Storage temperature and protection from light and moisture
- Refrigeration and usage timeframe for reconstituted suspension and vial