Avloclav BID (400 mg+57.50 mg)/5 ml (Powder for Suspension)

50 ml bottle: ৳ 245.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Aci limited
Also available as
Avloclav 250 mg tablet Avloclav 500 mg tablet Avloclav 875 mg tablet Avloclav 125 mg suspension Avloclav 500 mg injection Avloclav 1 gm injection

Indications

  • Short-term treatment of bacterial infections at various sites
  • Upper respiratory tract infections (e.g. tonsillitis, sinusitis, otitis media)
  • Lower respiratory tract infections (e.g. acute and chronic bronchitis, pneumonia)
  • Genito-urinary tract infections (e.g. cystitis, urethritis, pyelonephritis)
  • Skin and soft tissue infections
  • Bone and joint infections (e.g. osteomyelitis)
  • Other infections (e.g. septic abortion, puerperal sepsis)

Composition

  • Different tablet strengths: 375 mg, 625 mg, 1 gm
  • Different film-coated tablet compositions
  • Powder for Suspension composition
  • Injection composition with specific Amoxicillin and Clavulanic Acid content

Pharmacology

  • Broad spectrum bactericidal activity
  • Contains Amoxicillin and Clavulanic Acid
  • Inactivation of beta-lactamase enzymes
  • Extended antibiotic spectrum
  • Closely matched pharmacokinetics

Dosage

  • Different dosages for adults and children
  • Recommended dosage for various types and severity of infections
  • Instructions for suspension, forte suspension, and IV injection

Administration

  • Oral dosage form instructions
  • IV injection administration instructions
  • Utilization at the start of a meal for enhanced absorption

Interaction

  • Prolongation of bleeding time and prothrombin time
  • Potential reduction in efficacy of oral contraceptives
  • Concomitant use of allopurinol
  • Warning for patients

Contraindications

  • History of Penicillin hypersensitivity
  • Possible cross-sensitivity with other beta-lactam antibiotics
  • Contraindication for patients with previous Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

  • Uncommon side effects such as diarrhea, colitis, indigestion, nausea, vomiting, candidiasis
  • Rare side effects like hepatitis, cholestatic jaundice, urticarial and erythematous rashes
  • Instances of erythema multiforme, Stevens-Johnson Syndrome, exfoliative dermatitis
  • Potential angioedema and anaphylaxis

Pregnancy & Lactation

  • Animal studies show no teratogenic effect
  • Limited use in human pregnancy with no untoward effect
  • Not recommended in pregnancy unless essential
  • Detection of Amoxicillin in breast milk

Precautions & Warnings

  • Careful use in patients on anticoagulation therapy or with severe hepatic dysfunction
  • Dosage adjustment in moderate or severe renal impairment
  • Maintenance of adequate fluid intake and urinary output during high-dose administration

Use in Special Populations

  • Dose adjustment for patients with renal impairment
  • Specific dose recommendations for various levels of impairment
  • Caution and monitoring for patients with hepatic impairment

Overdose Effects

  • Unlikelihood of overdose problems
  • Possible gastrointestinal symptoms and electrolyte disturbance
  • Potential removal from circulation by haemodialysis

Therapeutic Class

  • Belongs to the category of broad spectrum penicillins

Reconstitution

  • Details about IV injection reconstitution
  • Restrictions on reconstitution or mixing with specific fluids

Storage Conditions

  • Storage temperature and protection from light and moisture
  • Refrigeration and usage timeframe for reconstituted suspension and vial

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