Corzil 80 mg (Tablet)

Unit Price: ৳ 22.00 (3 x 10: ৳ 660.00)
Strip Price: ৳ 220.00

Medicine Details

Category Details
Generic Azilsartan medoxomil
Company Aci limited
Also available as
Corzil 40 mg tablet

Indications

  • Treatment of hypertension
  • Lowering blood pressure
  • Reducing risk of cardiovascular events
  • May be used alone or in combination with other antihypertensive agents

Pharmacology

  • Formation of angiotensin II
  • Vasoconstriction
  • Stimulation of aldosterone
  • Cardiac stimulation
  • Renin-angiotensin system
  • ACE inhibitors
  • Selective blocking of AT1 receptor
  • Plasma concentrations
  • Renal reabsorption of sodium
  • Plasma renin activity
  • Plasma aldosterone concentrations
  • Plasma angiotensin I and II concentrations

Dosage & Administration

  • Recommended adult dose of 80mg orally once daily
  • Consider starting dose of 40mg for patients on high diuretic doses
  • Additional blood pressure reduction with concomitant use of other antihypertensive agents

Interactions

  • No interactions with amlodipine, antacids, chlorthalidone, digoxin, and more
  • Potential attenuation by non-steroidal anti-inflammatory drugs

Contraindications

  • Co-administration contraindicated with aliskiren in diabetes patients

Side Effects

  • Common adverse reaction of diarrhea
  • Other side effects include nausea, asthenia, fatigue, muscle spasm, dizziness, and cough

Pregnancy & Lactation

  • Pregnancy Category D
  • Risk to fetus in second or third trimester
  • Unknown excretion in human milk
  • Consideration for discontinuation of nursing

Precautions & Warnings

  • Use during second and third trimesters reduces fetal renal function
  • Potential symptomatic hypotension in volume-depleted patients
  • Possibility of changes in renal function including renal failure in renal impaired patients

Use in Special Populations

  • Neonatal reaction to in utero exposure
  • No established safety and effectiveness in pediatric patients
  • No dose adjustment for elderly patients
  • Likelihood of abnormally high serum creatinine values in elderly patients
  • No dose adjustment in mild-to-severe renal impairment or end-stage renal disease patients
  • Abnormally high serum creatinine values likely in moderate to severe renal impairment
  • No dose adjustment for mild or moderate hepatic impairment
  • Not studied in severe hepatic impairment

Overdose Effects

  • Limited data related to overdose in humans
  • Supportive therapy in case of overdose
  • Not dialyzable

Therapeutic Class

  • Angiotensin-ll receptor blocker

Storage Conditions

  • Keep in dry place away from light and heat
  • Keep out of reach of children

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