G-Thiopentone 1 gm/vial (IV Injection)
1 gm vial: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Thiopental sodium |
| Company | Gonoshasthaya pharma ltd |
| Also available as |
Product title
- G-Thiopentone for Injection
Product category
- Anesthetics
- Medication
- Pharmaceuticals
Indications
- Sole anesthetic agent for brief procedures
- Induction of anesthesia prior to administration of other agents
- Supplement for regional anesthesia
- Hypnosis during balanced anesthesia
- Control of convulsive states
- Neurosurgical patients with increased intracranial pressure
- Narcoanalysis and narcosynthesis in psychiatric disorders
Composition
- Thiopental 500 mg injection
- Thiopental 1 gm injection
- Sterile mixture of Thiopental Sodium and anhydrous Sodium Carbonate as a buffer
- Ampoule of 10 ml Water for Injection
Pharmacology
- Ultrashort-acting depressant of the central nervous system
- Induces hypnosis and anesthesia
- Binds at a distinct binding site associated with a Cl-ionopore at the GABA receptor
Dosage administration
- 2.5% w/v solution for intravenous administration
- Premedication with atropine or scopolamine
- Test dose for tolerance assessment
- Normal dosage for the induction of anesthesia
- Different dosages for adults, children, and elderly
Interaction
- Increase in difficulty in producing anaesthesia with alcohol or CNS depressants
- Additive action with other CNS depressants
- Increased hypotension and excitatory effects with phenothiazine antipsychotics
- Decreased requirement of G-Thiopentone with certain drugs
Contraindications
- Absence of suitable veins for intravenous administration
- Hypersensitivity to barbiturates
- Variegate porphyria or acute intermittent porphyria
- Status asthmaticus
- Severe cardiovascular disease
- Hypotension or shock
- Conditions prolonging or potentiating hypnotic effect
Side effects
- Hypersensitivity reactions
- Respiratory depression
- Myocardial depression
- Hypotension and tachycardia
- Bronchospasm and laryngospasm
- Anaphylactic reactions
Pregnancy lactation
- Pregnancy Category C
- Crosses placental barrier
- Small amounts may appear in the milk of nursing mothers
Precautions warnings
- Administration by competent anesthesia management personnel
- Caution in patients with preexisting hypotension or conditions intensifying hypnotic effect
- Habit-forming potential
- Availability of resuscitative and intubation equipment
- Avoid extravasations or intra-arterial injection
Overdose effects
- Too rapid injection leading to fall in blood pressure
- Apnoea and respiratory difficulties
Therapeutic class
- General (Intravenous) anesthetics
Storage conditions
- Controlled room temperature of 15°C to 30°C
- Freshly prepared solutions should be used immediately