TPS 1 gm/vial (IV Injection)
1 gm vial: ৳ 100.67
Medicine Details
| Category | Details |
|---|---|
| Generic | Thiopental sodium |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Sole anesthetic agent for brief procedures
- Induction of anesthesia
- Supplemental for regional anesthesia
- Hypnosis during balanced anesthesia
- Control of convulsive states
- Neurosurgical patients with increased intracranial pressure
- Narcoanalysis and narcosynthesis
Composition
- Thiopental 500 mg injection
- Thiopental 1 gm injection
- Sterile mixture of Thiopental Sodium and anhydrous Sodium Carbonate
- Ampoules of Water for Injection
Pharmacology
- Ultrashort-acting depressant of the central nervous system
- Induces hypnosis and anesthesia
- Binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor
- Increases duration of time for which the Cl- ionopore is open
- Prolongs the post-synaptic inhibitory effect of GABA in the thalamus
Dosage & Administration
- Administered intravenously as a 2.5% w/v solution
- Can be administered as a 5% w/v solution
- Premedication with atropine or scopolamine
- Test dose for tolerance assessment
- Normal dosage for induction of anesthesia
- Dosage adjustments based on patient's response
- Specific dosages for adults, children, and elderly
- Dosage for convulsive states
Interaction
- Increase in difficulty in producing anesthesia with alcohol or CNS depressants
- Additive action with other CNS depressants
- Increased hypotension and excitatory effects with phenothiazine antipsychotics
- Increased hypnotic effect with antipsychotic
- Decreased requirement of TPS with specific drugs
Contraindications
- Absence of suitable veins for intravenous administration
- Hypersensitivity to barbiturates
- Variegate porphyria or acute intermittent porphyria
- Status asthmaticus
- Severe cardiovascular disease
- Hypotension or shock
- Conditions prolonging or potentiating the hypnotic effect
Side Effects
- Hypersensitivity reactions
- Respiratory and myocardial depression
- Cardiac arrhythmias
- Prolonged somnolence and recovery
- Hypotension, tachycardia, bronchospasm
- Anaphylactic reactions
Pregnancy & Lactation
- Pregnancy Category C
- Potential fetal harm
- Crosses the placental barrier
- Presence in the milk of nursing mothers
Precautions & Warnings
- Constant attendance by anesthesia management personnel
- Caution in patients with preexisting hypotension
- Potential habit-forming nature
- Availability of resuscitative and intubation equipment
- Qualified personnel for administration
Overdose Effects
- Alarming fall in blood pressure
- Apnoea, laryngospasm, and respiratory difficulties
Therapeutic Class
- General (Intravenous) anesthetics
Storage Conditions
- Controlled room temperature of 15°C to 30°C
- Fresh preparation and immediate use
- Discarding remaining contents