Knil 60 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 95.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Rephco pharmaceuticals ltd
Also available as
Knil 10 mg tablet Knil 30 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease in eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins and acts as a peripherally acting analgesic
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound and largely metabolized in liver
  • Excretion in urine

Pharmacology

  • Acts by inhibiting the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours for short-term use only (up to 7 days)
  • Tablet maximum daily dose not to exceed 40 mg
  • Injection for management of moderately severe, acute pain requiring analgesia at the opioid level
  • IM administration should be given slowly and deeply into the muscle
  • Onset of analgesic effect within 30 minutes with maximum effect in 1 to 2 hours
  • Duration of analgesic effect is usually 4 to 6 hours
  • Eye Drops: Adults should use 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin: Increase the side effects of Knil
  • Anti-coagulants: Enhance anti-coagulant effect
  • Beta Blocker: Reduce the anti-hypertensive effect
  • ACE Inhibitors: Increase the risk of renal impairment
  • Methotrexate: Enhance the toxicity of methotrexate

Contraindications

  • Hypersensitivity to this drug or other NSAIDs
  • Not to be used in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in female
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over the age of 65 years
  • Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use in patients with evidence of corneal epithelial breakdown
  • Close monitoring for corneal health
  • Avoid use while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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