Osartek 50 mg (Tablet)
Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Pharmadesh laboratories ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily if 50 mg is inadequate
- Lower starting dose recommended for patients over 75 years
Interactions
- Rifampicin and fluconazole reduce active metabolite levels
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Risk of increased serum potassium with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Avoid administration with Aliskiren in diabetic patients
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion
- Other side effects include fatigue, edema, abdominal pain
Pregnancy & Lactation
- Pregnancy Category D
- Risk increases if administered during second or third trimesters
- Unknown excretion in human milk
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity
- Symptomatic hypotension in intravascularly volume-depleted patients
- Plasma concentration significantly increased in cirrhotic patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose recommended for moderate to severe renal impairment
- Lower dose recommended for patients with hepatic impairment
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Store in a dry place away from light and heat
- Keep out of the reach of children