Bevixa 100 mg/4 ml (IV Infusion)

100 mg vial: ৳ 20,000.00

Medicine Details

Category Details
Generic Bevacizumab
Company Incepta pharmaceuticals ltd
Also available as
Bevixa 400 mg injection

Indications

  • Metastatic colorectal cancer treatment with intravenous 5-fluorouracil-based chemotherapy
  • Metastatic colorectal cancer treatment with fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin based chemotherapy
  • Non-squamous non-small cell lung cancer treatment with carboplatin and paclitaxel
  • Glioblastoma treatment for adult patients with progressive disease
  • Metastatic renal cell carcinoma treatment with interferon alfa
  • Cervical cancer treatment in combination with paclitaxel and cisplatin or paclitaxel and topotecan
  • Recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment in platinum-resistant and platinum-sensitive cases

Pharmacology

  • Recombinant humanized monoclonal IgG1 antibody
  • Inhibits the biologic activity of human vascular endothelial growth factor (VEGF)
  • Approximate molecular weight of 149 kD
  • Produced in a mammalian cell expression system in a nutrient medium containing gentamicin
  • Clear to slightly opalescent, colorless to pale brown, sterile, pH 6.2 solution for intravenous infusion

Dosage

  • Recommended doses for metastatic colorectal cancer: 5 mg/kg or 10 mg/kg every 2 weeks
  • Recommended dose for non-squamous non-small cell lung cancer: 15 mg/kg every 3 weeks
  • Recommended dose for glioblastoma: 10 mg/kg every 2 weeks
  • Recommended dose for metastatic renal cell carcinoma: 10 mg/kg every 2 weeks
  • Recommended dose for cervical cancer: 15 mg/kg every 3 weeks
  • Recommended dose for platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer: 10mg/kg every 2 weeks or 15 mg/kg every 3 weeks
  • Recommended dose for platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer: 15 mg/kg every 3 weeks

Administration

  • Do not administer as an IV push or bolus
  • Initial infusion should be administered over 90 minutes
  • Subsequent infusions may be administered over 60 minutes or 30 minutes based on tolerance
  • Use appropriate aseptic technique for preparation
  • Visual inspection for particulate matter and discoloration prior to administration
  • Dilute in a total volume of 100 ml of 0.9% Sodium Chloride injection, USP

Interaction

  • No significant effect on the pharmacokinetics of irinotecan or its active metabolite SN38

Contraindications

  • No contraindications listed in the manufacturer’s labeling

Side Effects

  • Most common adverse reactions include epistaxis, headache, hypertension, rhinitis, proteinuria, taste alteration, dry skin, rectal hemorrhage, lacrimation disorder, back pain, and exfoliative dermatitis

Pregnancy & Lactation

  • May cause fetal harm based on findings from animal studies
  • Breastfeeding is not recommended during treatment

Precautions & Warnings

  • Discontinue if perforation or fistula occurs
  • Discontinue for severe arterial or venous thromboembolic events
  • Monitor and treat hypertension, discontinue for crisis or encephalopathy
  • Discontinue for posterior reversible encephalopathy syndrome or nephrotic syndrome
  • Stop for severe infusion reactions, advise on embryo-fetal toxicity and ovarian failure

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • Not approved for use in patients under the age of 18 years
  • Safety and efficacy in children with glioblastoma inadequately determined
  • Severe adverse events occurring at a higher incidence in patients aged 65 years and above
  • Effect on overall survival similar in elderly patients compared to younger patients

Overdose Effects

  • Highest tested dose associated with headache

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Store in a refrigerator at 2-8°C
  • Keep the vial in the outer carton due to light sensitivity
  • Do not freeze, keep out of reach of children

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