Clarizol 1% (Topical Solution)
20 ml bottle: ৳ 68.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of dermatomycoses due to dermatophytes
- Treatment of dermatomycoses due to yeasts
- Treatment of dermatomycoses due to moulds and other fungi
- Treatment of skin diseases showing superinfections with fungi
- Treatment of interdigital mycoses (e.g. athlete's foot)
- Treatment of paronychias (associated with nail mycoses)
- Treatment of mycoses in skin folds
- Treatment of Candida vulvitis
- Treatment of Candida balanitis
- Treatment of Pityriasis versicolor
- Treatment of erythrasma
Description
- Broad-spectrum antifungal agent
- Treats dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds, and bacteroids
- Active against certain gram-positive bacteria especially Staphylococci and Tricomonas
- Alters the permeability of fungal cell walls by interfering with cell wall lipids
- Inhibition of ergosterol synthesis
- Additional mechanism of membrane damage unrelated to sterol synthesis
Pharmacology
- Damages the permeability barrier in the cell membrane of fungi
- Inhibition of ergosterol biosynthesis
- Inhibition of lanosterol 14-demethylase (CYP51)
- Depletion of intracellular calcium
- Blocking of calcium-dependent potassium channels
- Blocking of voltage-dependent calcium channels
Dosage & Administration
- Thinly applied 2-3 times daily to the infected sites and rubbed in
- Small amount of cream is usually sufficient for an area about the size of the palm
- Reliable and sufficiently long-time application is important for complete success
- Recommended duration of treatment for different conditions
- Preventative treatment for fungal infection of the feet
- Topical solution should be applied sparingly and rubbed in gently two or three times daily
Interaction
- No information available
Contraindications
- Hypersensitivity to Clotrimazole
Side Effects
- Well tolerated when applied topically
- No systemic effects observed with external application
- Local irritation or burning sensation may occur in a very few cases
Pregnancy & Lactation
- Recommended to be used in pregnancy only when considered necessary by the physician
Therapeutic Class
- Drugs for subcutaneous and mycoses
- Topical Antifungal preparations
Storage Conditions
- Keep below 25°C temperature
- Keep away from light and moisture
- Keep out of the reach of children