Osartil 25 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Angiotensin-ll receptor blocker
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- Recommended dose adjustment for patients with intravascular volume-depletion
- Lower starting dose of 25 mg once daily for patients over 75 years
Interaction
- Reduction of active metabolite levels with Rifampicin and fluconazole
- Potentiation of antihypertensive effects with concomitant use of hydrochlorothiazide
- Increases in serum potassium with concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium
- Attenuation of antihypertensive effect with non-steroidal anti-inflammatory drug indomethacin
- Increased risk of renal impairment with the use of ACE-inhibitor, angiotensin receptor antagonist, an anti-inflammatory drug, and a thiazide diuretic at the same time
Contraindications
- Pregnant women
- Hypersensitivity to any component of the product
- Administration with Aliskiren in patients with diabetes
Side Effects
- Dizziness
- Diarrhea
- Nasal congestion
- Cough
- Upper respiratory infection
- Fatigue
- Edema
- Abdominal pain
- Chest pain
- Nausea
- Headache
- Pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to the fetus when administered during the second or third trimesters
- Unknown excretion in human milk
- Potential adverse effects on the nursing infant
Precautions & Warnings
- Reduction of fetal renal function and increase in fetal and neonatal morbidity and death during the second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Reported changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment or patients on dialysis
- Lower dose consideration for patients with a history of hepatic impairment
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children