Osartil 50 mg (Tablet)
Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50mg once daily
- Additional dosage adjustments for specific patient groups
- Total daily dose ranges from 25mg to 100mg
Interaction
- Effects of concomitant medications like rifampicin, fluconazole, hydrochlorothiazide, potassium-sparing diuretics, potassium supplements, salt substitutes
- Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drugs
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Avoid use with aliskiren in diabetic patients
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus in second or third trimesters
- Unknown excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death in second and third trimesters
- Potential symptomatic hypotension in intravascularly volume-depleted patients
- Plasma concentration increase in cirrhotic patients
- Changes in renal function reported in renal-impaired patients
Use in Special Populations
- Dosage adjustment in renal impairment
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Lower dose consideration for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children