Dormicum 7.5 mg (Tablet)

Indications

• Short-term treatment of insomnia
• Sedation in premedication before surgical or diagnostic procedures

Description

A sleep-inducing agent characterized by rapid onset and short duration of action. It also exerts an anxiolytic, anticonvulsant, and muscle-relaxant effect.

Pharmacology

Benzodiazepines such as midazolam increase the activity of GABA, thereby producing a sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia. They bind to the benzodiazepine site on GABA-A receptors.

Dosage & Administration

• Oral dosage for adults: 7.5-15 mg daily
• Oral dosage for elderly and debilitated patients: 7.5 mg
• Oral dosage in premedication: 15 mg 30-60 minutes before the procedure
• Intravenous administration for endoscopic or cardiovascular procedures: Initial dose approximately 2.5 mg in healthy adults
• Intravenous administration for induction of anesthesia: 10-15 mg

Interaction

Dormicum can enhance the central sedative effect of various other drugs such as neuroleptics, antidepressants, analgesics, anesthetics, antipsychotics, and sedative antihistamines.

Contraindications

Must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, and known hypersensitivity to benzodiazepines or any component of the product.

Side Effects

• At the start of therapy: drowsiness, confusion, fatigue, headache, muscle weakness
• Following parenteral administration: fluctuations in vital signs including respiratory depression, apnea, variations in blood pressure, and pulse rate

Pregnancy & Lactation

Should be avoided during pregnancy unless there is no safer alternative. It passes into breast milk, so should not be administered to breastfeeding mothers.

Precautions & Warnings

Dormicum IV should be administered very slowly.

Overdose Effects

Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression, and apnea. Overdosage effects can be controlled with benzodiazepine antagonist flumazenil.

Therapeutic Class

• Benzodiazepine hypnotics
• Benzodiazepine sedatives

Storage Conditions

Protect from light and moisture. Store in a cool and dry place. Keep out of the reach of children.

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