Osartil 100 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- Total daily dose ranges from 25 mg to 100 mg
- Different starting dose for patients with intravascular volume-depletion
- Lower starting dose for patients over 75 years
Interaction
- Reduction of active metabolite levels by Rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increase in serum potassium with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Pregnant women
- Hypersensitivity to any component
- Concurrent use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient nature
- Common side effects: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects: fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus if administered during second or third trimesters
- Potential excretion in human milk
- Consideration for discontinuation of nursing or drug based on importance to the mother
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in patients with renal impairment
Use in Special Populations
- No initial dosage adjustment for patients with mild renal impairment
- Lower starting dose for patients with moderate to severe renal impairment or on dialysis
- Consideration of lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children