Orizone 500 mg/vial (IV Injection)

500 mg vial: ৳ 200.60 (5's pack: ৳ 1,003.00)

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Pharmacil limited
Also available as
Orizone 1 gm injection Orizone 2 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High degree of stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • Highly protein bound (95%)
  • Excretion in urine and bile

Dosage

  • Usual adult dose of 1 to 2 gm by intravenous or intramuscular administration once a day
  • Different doses for specific infections and age groups
  • Duration of therapy for more than 2 days after signs and symptoms of infection have disappeared

Administration

  • Preparation of solutions for intramuscular / intravenous injections
  • Intramuscular and intravenous injection methods
  • Tubing infusion over a period of 30 minutes
  • Patient tolerance test before treatment
  • Solution stability at room temperature or 5°C

Interaction

  • No reported drug interactions

Contraindications

  • Not to be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, and vomiting
  • Cutaneous reactions including rash, pruritus, and urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia, and anemia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, and headache
  • Local phlebitis following intravenous administration

Pregnancy & Lactation

  • Safety in human pregnancy not established
  • Caution in lactating mothers

Precautions & Warnings

  • Potential for anaphylactic shock
  • Possibility of shadows suggesting sludge in gallbladder
  • Regular blood picture checks during prolonged treatment

Use in Special Populations

  • Not to be given to premature and newborn neonates (up to 28 days of age)

Overdose Effects

  • No specific antidote
  • Symptomatic treatment

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30° C)
  • Keep away from light and moisture
  • Keep out of the reach of children

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